Håkan Billig

Projects | Publications

Position: Head of Division

Title: M.D. Ph.D

E-mail: hakan.billig@fysiologi.gu.se

Project
Reproduktion and metabolism - endocrine interaction: regulation of follicular apoptosis and prolactin effects on adipose tissue

Address
Institute of Neuroscience and Physiology
Dept. of Physiology/Endocrinology
The Sahlgrenska Academy at University of Gothenburg
Medicinaregatan 11
P.O. Box 434, SE-405 30 Göteborg
SWEDEN
Phone +46 31 786 3534
Fax +46 31 786 3512

Publications

• Friberg PA, Larsson DGJ, Billig H. Transcriptional effects of progesterone receptor antagonist in rat granulosa cells. Mol Cell Endocrinol 2010; 315:121-130.
   
• Clomiphene citrate causes aberrant tubal apoptosis and estrogen receptor activation in rat fallopian tube: implications for tubal ectopic pregnancy Shao R, Nutu M, Weijdegård B, Egecioglu E, Fernandez-Rodriguez J, Karlsson-Lindahl L, Gemzell-Danielsson K, Bergh C, and Billig H Biol Reprod 2009 In Press
   
• Friberg P.A., Larsson D.G., Billig H., 2009. Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis. Biol Reprod. 80, 1160-1167.
   
• Ruijin Shao, Emil Egecioglu, Birgitta Weijdegard, John J Kopchick, Julia Fernandez-Rodriguez, Niklas Andersson, and Hakan Billig. Dynamic regulation of estrogen receptor alpha isoform expression in the mouse fallopian tube: mechanistic insight into estrogen-dependent production and secretion of insulin-like growth factors  Am J Physiol Endocrinol Metab (September 11, 2007). doi:10.1152/ajpendo.00384.2007
   
• Friberg PA, Larsson DG, Rung E, Billig H.
  Apoptotic effects of a progesterone receptor antagonist on rat granulosa cells are not mediated via reduced protein isoprenylation.
  Mol Reprod Dev. Published Online: 6 Mar 2007. DOI: 10.1002/mrd.20711
   
• Ciliated epithelial-specific and regional-specific expression and regulation of the estrogen receptor beta2 in the fallopian tubes of immature rats
  Ruijin Shao, Birgitta Weijdegård, Julia Fernandez-Rodriguez, Emil Egecioglu, Changlian Zhu, Niklas Andersson, Ann Thurin-Kjellberg, Christina Bergh, and Håkan Billig
  Am J Physiol Endocrinol Metab (March 20, 2007). doi:10.1152/ajpendo.00101.2007
   
• Nutu M, Weijdegard B, Thomas P, Bergh C, Thurin-Kjellberg A, Pang Y, Billig H, Larsson DG.
  Membrane progesterone receptor gamma: Tissue distribution and expression in ciliated cells in the fallopian tube. Mol Reprod Dev. 2006 Dec 8
   
• Estrogen-Induced Up-Regulation of Androgen Receptor (AR) Expression and Enhancement of AR Nuclear Translocation in Mouse Fallopian Tubes in vivo
  Ruijin Shao, Karin Ljungström, Birgitta Weijdegård, Emil Egecioglu, Julia Fernandez-Rodriguez, Fu-Ping Zhang, Ann Thurin-Kjellberg, Christina Bergh, and Håkan Billig
  Am J Physiol Endocrinol Metab (October 17, 2006). doi:10.1152/ajpendo.00350.2006
   
• Rung E, Friberg PA, Bergh C, Billig H.
  Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells.
  Mol Reprod Dev 2006.
   
• Shao R, Egecioglu E, Weijdegard B, Ljungstrom K, Ling C, Fernandez-Rodriguez J, Billig H.
  Developmental and hormonal regulation of progesterone receptor A-form expression in female mouse lung in vivo: interaction with glucocorticoid receptors. J Endocrinol. 2006 Sep;190(3):857-70.
   
• Ruijin Shao, Birgitta Weijdegrd, Karin Ljungstrom, Anders Friberg, Changlian Zhu, Xiaoyang Wang, Yihong Zhu, Julia Fernandez-Rodriguez, Emil Egecioglu, Emilia Rung, and Hakan Billig
  Nuclear Progesterone Receptor (PR) A and B Isoforms in Mouse Fallopian Tube and Uterus: Implications for Expression, Regulation and Cellular Function  Am J Physiol Endocrinol Metab (January 31, 2006). doi:10.1152/ajpendo.00582.2005
   
• Shao R, Rung E, Weijdegard B, Billig H
  Induction of apoptosis increases SUMO-1 protein expression and conjugation in mouse periovulatory granulosa cells in vitro. Mol Reprod Dev. 2006 Jan;73(1):50-60.
   
• Louise Nilsson, Nadine Binart, Mohammad Bohlooly-Y, Margareta Bramnert, Emil Egecioglu, Jon Kindblom, Paul A. Kelly, John J. Kopchick, Christopher J. Ormandy, Charlotte Ling, Håkan Billig. Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue.  Biochem Biophys Res Commun, 2005; 331: 1120-1126.
   
• Chen Y, Lasaitiene D, Gabrielsson BG, Carlsson LM, Billig H, Carlsson B, Marcussen N, Sun XF, Friberg P. Neonatal losartan treatment suppresses renal expression of molecules involved in cell-cell and cell-matrix interactions. J Am Soc Nephrol. 2004 May;15(5):1232-43.
   
• Shao R, Zhang FP, Tian F, Anders Friberg P, Wang X, Sjoland H, Billig H. Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo. FEBS Lett. 2004 Jul 2;569(1-3):293-300.
   
• Emilia Rung, P. Anders Friberg, Ruijin Shao, D.G. Joakim Larsson, Eva Ch. Nielsen, Per-Arne Svensson, Björn Carlsson, Lena M.S. Carlsson, and Håkan Billig.
  Progesterone Receptor Antagonists and Statins Decrease De Novo Cholesterol Synthesis and Increase Apoptosis in Rat and Human Periovulatory Granulosa Cells in Vitro. Biol Reprod published 22 Sept 2004; 10.1095/biolreprod.104.033878
   
• Ruijin Shao, Fu-Ping Zhang, Emilia Markström, Jorma J. Palvimo, Ilpo Huhtaniemi, and Håkan Billig Inhibition of SUMO-1 Expression by LH Receptor Stimulation is Linked to Induction of Progesterone Receptor During Ovulation in Mouse Granulosa Cells
  Endocrinology 2004 Jan; 145(1): 384-92.
   
• Hashemi SH, Benjegard SA, Ahlman H, Wangberg B, Forssell-Aronsson E, Billig H, Nilsson O.
  111In-labelled octreotide binding by the somatostatin receptor subtype 2 in neuroendocrine tumours. Br J Surg. 2003 May;90(5):549-54.
   
• Per-Arne Svensson, Mikael CO Englund, Emilia Markström, Bertil G Ohlsson, Margareta Jernås, Håkan Billig, Jarl S Torgerson, Olov Wiklund, Lena MS Carlsson, Björn Carlsson. Copper induces the expression of cholesterogenic genes in human macrophages. Atherosclerosis. 2003 Jul;169(1):71-6.
   
• Kadi F, Karlsson C, Larsson B, Eriksson J, Larval M, Billig H, Jonsdottir IH.
  The effects of physical activity and estrogen treatment on rat fast and slow skeletal muscles following ovariectomy. J Muscle Res Cell Motil. 2002;23(4):335-9. PMID: 12630708
   
• Billig H, Markstrom E, Svensson EC, Shao R, Friberg A.
  Follicular development and apoptosis. Ernst Schering Res Found Workshop. 2002;(41):23-41. No abstract available. PMID: 12402538
   
• Charlotte Ling, Louise Svensson, Birgitta Odén, Birgitta Weijdegård, Barbro Edén, Staffan Edén, Håkan Billig
  Identification of functional prolactin (PRL) receptor gene expression; PRL inhibits lipoprotein lipase activity in human white adipose tissue.  J Clin Endocrinol Metab. 2003 Apr;88(4):1804-8
   
• Ruijin Shao, Emilia Markström, P. Anders Friberg, Maria Johansson and Håkan Billig
  Expression of progesterone receptor A and B isoforms in mouse granulosa cells: stage-dependent PR-mediated regulation of apoptosis and cell proliferation
  Biology of Reproduction. 2003. 68:914-921.
   
• Markström E, Svensson E Ch, Shao R, Svanberg B, Billig H (2002) Survival factors regulating ovarian apoptosis: Dependence on follicle differentiation.Reproduction.123:23-30.
   
• Johnson MSC, Svensson PA, Boren J, Billig H, Carlsson LMS, Carlsson B (2002) Expression of scavenger receptor class B type 1 in gallbladder columnar J Gastroenterol Hepatol.17:713-720.)
   
• Ling C, Kindblom J ,Wennbo H, Billig H. (2001) Increased resistin expression in the adipose tissue of male prolactin transgenic mice and in male mice with elevated androgen levels. FEBS Letters, 507:147-50
   
• Ling C, Billig H (2001) Prolactin receptor mediated effects in female mouse adipocytes: PRL induces suppressors of cytokine signaling (SOCS) mRNA expression and suppresses insulin-induced leptin production in adipocytes in vitro. Endocrinology 142:4880-4890
   
• Svensson EC, Markström E, Shao R, Andersson M and Billig H (2001) Progesterone promotes survival of periovulatory human granulosa cells: Org 31710 and RU 486 increase caspase-mediated apoptosis. Fertil Steril,. 76:1225-31.
   
• Vaskivuo TE, Anttonen M, Herva R, Billig H, Dorland R, Te Velde ET, Stenbäck F, Heikinheimo M, Tapanainen JS (2001) Survival of human ovarian follicles from fetal to adult life: apoptosis, apoptosis-related proteins, and transcription factor GATA-4J Clin Endocrinol Metab. 86(7):3421-9
   
• Hellgren G, Albertsson-Wikland K, Billig H, Carlsson LM, Carlsson B. (2001) Growth hormone receptor interaction with jak proteins differs between tissues. J Interferon Cytokine Res. 21(2):75-83.
   
• Ling C, Hellgren G, Gebre-Medhin M, Dillner K, Wennbo H, Carlsson B, Billig H (2000) Prolactin (PRL) receptor gene expression in mouse adipose tissue: increases during lactation and in PRL-transgenic mice. Endocrinology. 141(10):3564-72.
   
• Svanberg B, Ling C, Svensson PA, Johnson M, Carlsson B, Billig H.(2000) Isolation of differentially expressed aldose reductase in ovaries after estrogen withdrawal from hypophysectomized diethylstilbestrol treated rats: increased expression during apoptosis. Mol Cell Endocrinol. 164(1-2):183-90
   
• Svensson EC, Markstrom E, Andersson M, Billig H. (2000) Progesterone receptor-mediated inhibition of apoptosis in granulosa cells isolated from rats treated with human chorionic gonadotropin. Biol Reprod. 63(5):1457-64.
   
• Sundfeldt K, Piontkewitz Y, Billig H, Hedin L. (2000) E-cadherin-catenin complex in the rat ovary: cell-specific expression during folliculogenesis and luteal formation. J Reprod Fertil. 118(2):375-85
   
• Svanberg B, Billig H. (1999) Isolation of differentially expressed mRNA in ovaries after estrogen withdrawal in hypophysectomized diethylstilbestrol-treated rats: increased expression during apoptosis. J Endocrinol. 163(2):309-16.
   
• Svensson PA, Johnson MS, Ling C, Carlsson LM, Billig H, Carlsson B. (1999) Scavenger receptor class B type I in the rat ovary: possible role in high density lipoprotein cholesterol uptake and in the recognition of apoptotic granulosa cells. Endocrinology. 140(6):2494-500
   
• Johnson MSC, Svensson PA, Helou K, Billig H, Levan G, Carlsson LMS, Carlsson B (1998) Characterization and chromosomal localization of rat scavenger receptor Class B Type I - a high density lipoprotein receptor with a putative leucine zipper domain and peroxisomal targeting sequence , Endocrinology, 139:72-80
   
• Billig H, Svensson E, Hsueh AJW (1998) Direct and quantitative gel-based DNA fragmentation assay using radioisotopes. In: Apoptosis. Detection and assay methods. Bio Techniques Molecular Laboratory Methods Series. Zhu L and Chun J (eds.). Eaton Publishing. pp 15-22
   
• Nilsson O, Kölby L, Wängberg B, Wigander A, Billig H, William-Olsson L, Fjälling M, Forsell-Aronsson E, Ahlman H (1998). Comparative studies on the expression of somatostatin receptor subtypes, outcome of octretide scintigraphy and response to octretide treatment in patients with carcinoid tumours. Br J Cancer 77(4), 632-637
   
• Karlsson-C; Lindell-K; Svensson-E; Bergh-C; Lind-P; Billig-H; Carlsson-LMS; Carlsson-B (1997) Expression of functional leptin receptors in the human ovary J Clin Endo Metab 82 (12) : 4144-4148
   
• Benson M, Kjellmer I, Rosberg S, Billig H (1997) Can Paediatritians benefit from the Internet? Arch. Disease Childhood 77:179-182
   
• McGee E., Spears N., Minami S, Hsu S-Y., Chun S-Y, Billig H, Hsueh AJW (1997) Preantral ovarian follicles in serum-free culture: Suppression of apoptosis following activation of cGMP pathway and stimulation of growth and differentiation. Endocrinology, 138:2417-2424
   
• Hsueh AJW, Eisenhauer K, Chun SY, Hsu SY, Billig H (1996) Gonadal cell apoptosis. Rec Prog Horm Res, 15:433-456.
   
• Billig H (1996) Follicle apoptosis. Gyn Endocrinol 10:suppl 4:7-8
   
• Billig H, Chun Y, Eisenhauer KM, Hsueh AJW (1996) Gonadal cell apoptosis: Hormone-regulated cell demise. Hum Reprod Update 2:103-117
   
• översikter/kapitel Billig H, Hsueh AJW (1996) Hormonal control of apoptosis in gonadal tissues. In:Apoptosis in normal development and in cancer. Sluyser M (ed). Taylor and Francis,, London. pp 201-221
   
• Hsueh AJW, Eisenhauer K, Chun SY, Hsu SY, Billig H (1996) Gonadal cell apoptosis. Rec Prog Horm Res, in press.
   
• Billig H (1996) Follicle apoptosis. Gyn Endocrinol 10:suppl 4:7-8
   
• Heiskanen P, Billig H, Toppari J, Kalev M, Arsalo A, Rapola J, Dunkel L (1996) Apoptotic cell death in the normal and cryptorchid human testis: The effect of human chorionic gonadotropin on testicular cell survival. Ped Res 40:351-356
   
• Billig H, Chun Y, Eisenhauer KM, Hsueh AJW (1996) Gonadal cell apoptosis: hormone-regulated cell demise. Hum Reprod Update 2:103-117
   
• Billig H, Hsueh AJW (1996) Hormonal control of apoptosis in gonadal tissues.In:Apoptosis in normal development and in cancer. Sluyser M (ed). Taylor and Francis, London. pp 201-221
   
• Chun SY, Eisenhauer KM, Minami S, Billig H, Perlas E, Hsueh AJW (1996) Hormonal regulation of apoptosis in early antral follicles: Follicle-stimulating hormone as a major survival factor. Endocrinology 137:1447-1456
   
• Billig H, Assarsson B, Björnheden D, Svensson E, Thelander H, Utter M (1995) Atresia as an apoptotic process. Frontiers in Endocrinology. Gonadal function-Genetics to Physiology (Eds Hillensjö, Ahrén) 18:21-34
   
• Eisenhauer K, Chun SY, Billig H, Hsueh AJW (1995) Growth hormone suppression of apoptosis in preovulatory follicles and partial neutralization by insulin-like growth factor binding protein (IGFBP) Biol Reprod 53:13-20
   
• Billig H, Furuta I, Rivier C, Tapanainen J, Parvinen M, Hsueh AJW (1995) Apoptosis in testis germ cells: Developmental changes in gonadotropin dependence and localization to selective tubule stages. Endocrinology 136:5-12
   
• Shikone T, Billig H, Hsueh AJW (1994) Experimentally induced cryptorchidism increases apoptotis in rat testis. Biol Reprod 51:865-872
   
• Chun SY, Billig H, Tilly JL, Furuta I, Tsafriri A, Hsueh AJW (1994) Gonadotropin suppression of apoptosis in cultured preovulatory follicles: mediatory role of endogenous insulin-like growth factor I. Endocrinology 135:1845-1853
   
• Billig H, Furuta I, Hsueh AJW (1994) Gonadotropin releasing hormone (GnRH) directly induces apoptotic cell death in the rat ovary: Biochemical and in situ detection of DNA fragmentation in granulosa cells. Endocrinology 134:245-252
   
• Hsueh AJW, Billig H, Tsafriri A (1994) Ovarian follicle atresia: A hormonally controlled apoptotic process. Endocrine Rev 15:707-724
   
• Hsueh AJW, Tapanainen J, Furuta I, Billig H (1994) Gonadotropin control of follicle ovulation, luteinization and atresia. Proceedeings, International IVF meeting, Tokyo, Japan
   
• Hsueh AJW, Billig H (1994) Ovary: Control of follicle atresia. Current Opinion in Endocrinology and Diabetes 192-199
   
• Hsueh AJW, Billig H (1994) Ovarian hormone synthesis and mechanism of action. In: Endocrinology, 3rd edition (Eds DeGroot), Vol 3, pp.2019-2030.
   
• Carlsson B, Hillensjö T, Nilsson A, Törnell J, Billig H (1993) Expression of insulin-like growth factor-I (IGF-I) in rat Fallopian tube: possible autocrine and paracrine action of Fallopian tube-derived IGF-I on the Fallopian tube and on the preimplantation embryo. Endocrinology 133:2031-2039
   
• Billig H, Furuta I, Hsueh AJW (1993) Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis. Endocrinology 133:2204-2212
   
• Tapanainen JS, Bo M, Dunkel L, Billig H, Perlas EA, Biome I, Hsueh AJW (1993) Deglycosylation of the human luteinizing hormone receptor does not affect ligand binding and signal transduction. Endocrine J 1:219-225
   
• Carlsson B, Nilsson A, Isaksson OGP, Billig H (1993) Growth hormone-receptor messenger RNA in the rat ovary: regulation and localization. Mol Cell Endocrinol, 95:59-66
   
• Carlsson B, Bergh C, Bentham J, Olsson J-H, Norman M, Billig H, Hillensjö T (1992) Expression of functional growth hormone receptors in human granulosa cells. Hum Reprod 7:1205-1209
   
• Tilly JL, Billig H, Kowalski KI, Hsueh AJW (1992) Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism. Mol Endocrinol 6:1942-1950
   
• Tilly JL, Aihara T, Nishimori K, Jia X-C, Billig H, Kowalski KI, Perlas EA, Hsueh AJW (1992) Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts. Endocrinology 131:799-806
   
• Bergh C, Carlsson B, Ohlsson JH, Billig H, Hillensjö T (1991) Effects of insulin-like growth factor I and growth hormone in cultured human granulosa cells. Ann NY Acad Sci 626:169-76
   
• Carlsson B, Billig H (1991) Insulin-like growth factor-I gene expression during development and estrous cycle in the rat uterus. Mol Cell Endocrinol 77:175-180
   
• Vikman K, Carlsson B, Billig H, Eden S (1991) Expression and regulation of growth hormone (GH) receptor messenger ribonucleic acid (mRNA) in rat adipose tissue, adipocytes, and adipocyte precursor cells: GH regulation of GH receptor mRNA.Endocrinology 129:1155-1161
   
• Törnell J, Hillensjö T, Billig H (1991) Regulation of oocyte maturation by changes in ovarian levels of cyclic nucleotides. Hum Reprod 6:411-422
   
• Törnell J, Billig H, Hillensjö T (1990) Resumption of rat oocyte meiosis is paralleled by a decrease in guanosine 3',5'cyclic-monophosphate (cGMP)- and adenosine 3',5'cyclic-monophosphate (cAMP)-levels and is inhibited by microinjection of cGMP and cAMP. Acta Physiol Scand 139:511-517
   
• Törnell J, Brännström M, Magnusson C, Billig H (1990) Effects of follicle stimulating hormone and purines on rat oocyte maturation. Mol Reprod Dev 27:254-260
   
• Törnell J, Carlsson B, Billig H (1990) Atrial natriuretic peptide inhibits spontaneous rat oocyte maturation. Endocrinology 126:1504-1508
   
• Carlsson B, Billig H, Rymo L, Isaksson OGP (1990) Expression of the growth hormone-binding protein in the liver and in extrahepatic tissues in the rat: Co-expression with the growth hormone receptor. Mol Cell Endocrinol 73:R1-R6
   
• Jansson J O, Carlsson L, Ekberg S, Isgaard J, Carlsson B, Billig H, Adamo M, LeRoith D (1990) Pulsatile GH secretory pattern in relation to local production of growth factors in the rat. Acta Paediatr Scand (suppl) 367:98-102
   
• Hansson H A, Billig H, Isgaard J (1989) Insulin-like growth factor I in the rat testis: Immunohistochemical aspects. Biol Reprod 40:1321-1328
   
• Ekberg S, Carlsson L, Carlsson B, Billig H, Jansson J O (1989) Plasma growth hormone pattern regulates epidermal growth factor (EGF) receptor messenger ribonucleic acid levels and EGF-binding in the rat liver. Endocrinology 125:2158-2166
   
• Carlsson B, Carlsson L, Billig H (1989) Estrus cycle-dependent co-variations of the level of insulin-like growth factor-I (IGF-I) messenger ribonucleic acid and protein in the rat ovary. Mol Cell Endocrinol 64:271-275
   
• Billig H, Kumai A, Rosberg S (1989) Adenosine receptor-mediated effects on adenylate cyclase activity in rat luteal tissue. A putative local regulatory role of adenosine in the corpus luteum. Biol Reprod 40:102-110
   
• Billig H, Carlsson B, Nilsson A, Rymo L, Ahrén K (1989) Regulation of IGF-I mRNA in the rat ovary and reproductive tract. In: Follicular development and the ovulatory response. Serono Symposia No. 23. (Eds. Tsafriri A and Dekel N) Ares-Serono Symposia, Rome. pp. 253-261
   
• Billig H, Rosberg S, Johanson C, Ahrén K (1989) Adenosine as substrate and receptor agonist in the ovary. Steroids 54:523-542
   
• Hansson H A, Nilsson A, Isgaard J, Billig H, Isaksson OG P, Skottner A, Andersson I K, Rozell B (1988) Immunohistochemical localization of IGF-I in adult rat. Histochemistry 89:403-410
   
• Billig H, Rosberg S (1988) Evidence for A2 adenosine receptor-mediated effects on adenylate cyclase activity in rat ovarian membranes. Mol Cell Endocrinol 56:205-210
   
• Billig H, Thelander H, Rosberg S (1988) Adenosine receptor-mediated effects by nonmetabolizable adenosine analogs in preovulatory rat granulosa cells: A putative local regulatory role of adenosine in the ovary. Endocrinology 122:52-61
   
• Billig H (1988) Adenosine and ovarian function. Studies on adenosine as substrate and receptor agonist. Thesis. Dept of Physiology, University of Göteborg, Göteborg. Vol. ISBN 91-7900-439-3, pp. 1-46
   
• Billig H, Törnell J, Carlsson B, Hillensjö T, Ahrén K (1988) Hormonal regulation of oocyte maturation. In: Development and function of reproductive organs. (Eds. Parvinen M Huhtaniemi I and Pelliniemi LJ) Ares-Serono Symposia, Rome. Vol. II, pp. 161-170
   
• Billig H, Rosberg S (1986) Gonadotropin depression of adenosine triphosphate levels and interaction with adenosine in rat granulosa cells. Endocrinology 118:645-652
   
• Andersson I, Billig H, Fryklund L, Hansson H A, Isaksson OG P, Isgaard J, Nilsson A, Rozell B, Skottner A, Stemme S (1986) Localization of IGF-I in adult rats. Immunohistochemical studies. Acta Physiol Scand 126:311-312
   
• Hillensjö T, Billig H, Chari S, Daume E, Sturm G (1986) Local inhibitors of progesterone secretion. In: Gynecology and Obstetrics. (Eds. Ludwig H) Springer Verlag, Berlin Heidelberg. pp. 827-829
   
• Billig H, Magnusson C (1985) Gonadotrophin-induced inhibition of oxygen consumption of rat oocyte-cumulus complexes: relief by adenosine. Biol Reprod 33:890-898
   
• Billig H, Sheela Rani C S, Ekholm C, Magnusson C, Hillensjö T (1984) Effect of a GnRH analogue on rat granulosa cell glycolysis in vitro. Acta Endocrinol 105:112-118
   
• Sheela Rani C S, Ekholm C, Billig H, Magnusson C, Hillensjö T (1983) Biphasic effects of gonadotropin releasing hormone on progestin secretion by rat granulosa cells. Biol Reprod 28:591-597
   
• Billig H, Hillensjö T, Tsafriri A, Magnusson C, Brodie A (1983) Nuclear maturation of follicle-enclosed rat oocytes during inhibition of steroidogenesis. Gamete Res 8:79-86
   
• Billig H, Hedin L, Magnusson C (1983) Gonadotrophins stimulate lactate production by rat cumulus granulosa cells. Acta Endocrinol 103:562-566
   
• Ahrén K, Billig H, Clark M R, Ekholm C, Hillensjö T, LeMaire W J, Magnusson C, Sheela Rani C S (1983) Acute stimulatory effects of luteinizing hormone-releasing hormone (LHRH) and LHRH analogues on the preovulatory rat follicle. J Steroid Biochem 19:119-125
   
• Hillensjö T, Magnusson C, Ekholm C, Billig H, Hedin L (1982) Role of cumulus cells in oocyte maturation. Adv Exp Med Biol 147:175-188
   
• Magnusson C, Billig H, Eneroth P, Roos P, Hillensjö T (1982) Comparison between the progestin secretion responsiveness to gonadotrophins of rat cumulus and mural granulosa cells in vitro. Acta Endocrinol 101:611-616