Joakim Larsson

Projects | Publications | CV

Position: Associate professor

Title: M.Sc. Ph.D Docent

E-mail: joakim.larsson@fysiologi.gu.se

Projects
Resistance in environmental bacteria evolving under extreme antibiotic selection pressure – characterization of the resistance genes we may face tomorrow

Pharmaceutical pollution – antibiotic resistance development and mode-of-action based test strategies

Microbial diversity and development of antibiotic resistance associated with industrial wastewater treatment

Consumption of inexpensive medicines – increased risks for resistance development and environmental effects?

Endocrine disruption of non-genomic progesterone signalling – consequences for gamete transport and sex ratios

BALCOFISH - Integration of pollutant gene responses and fish ecology in Baltic coastal fisheries and management

MistraPharma - Identification and Reduction of Environmental Risks Caused by the Use of Human Pharmaceuticals

Multi-Endpoint Microarray Analyses in Biological Effect Monitoring of Wild Fish Populations
Ecotoxicology – from gene to ocean

Metabolic processes underlying seasonal growth patterns in fish

How does progesterone control programmed cell death – specific roles of membrane progesterone receptors

Group members
Magdalena Nutu
Lina Gunnarsson
Dr Linda Samuelsson
Dr Jeff Brown
Eva Albertsson
Andreas Kullgren
Filip Cuklev
Erik Kristiansson
Dr Noomi Asker
Birgitta Weijdegård
Carolin Rutgersson
Anna Bylander

Address
Institute of Neuroscience and Physiology
Dept. of Physiology/Endocrinology
The Sahlgrenska Academy at University of Gothenburg
Medicinaregatan 11
P.O. Box 434, SE-405 30 Göteborg
SWEDEN
Phone +46 31 786 3589
Fax +46 31 786 3512

Books / book chapters / reviews

• Larsson DGJ. Release of active pharmaceutical ingredients from manufacturing sites – need for new management strategies. Integrated Environmental Assessment and Management. In press.

• Rudén C, Brandt I, Breitholtz M, Fick J, la Cour Jansen J, Larsson DGJ, Tysklind M. 2009. Feminized Fish and Vulnerable Vultures – Pharmaceuticals as Environmental Pollutants Require Novel Testing Approches. Pp 148-165. In: A healthy future – Pharmaceuticals in a Sustainable Society. Eds Bengtsson B-E et al. Apoteket AB, Stockholm Sweden. ISBN:2184-01. Available in both English and Swedish.
   

• Larsson DGJ. 2008. Drug production facilities – an overlooked discharge source for pharmaceuticals to the environment. In Kümmerer K, ed, Pharmaceuticals in the Environment. Sources, Fate, Effects, and Risks. Springer, New York, NY, USA, pp 37-42.
   
• Samuelsson L.M and Larsson D.G.J. 2008. Contributions from metabolomics to fish research. Molecular Biosystems 4:974–979  
   
• Tyler C.R., Filby A., Iguchi T., Kramer V, Larsson D.G.J., van Aggelen G., van Leeuwen C., Viant M., Tillitt D. 2007. Application of Genomics to Tiered Testing. In: Molecular Biology and Risk Assessment: Evaluation of the Potential Roles of Genomics in Regulatory Ecotoxicology (ed. Ankley G). Society of Environmental Toxicology and Chemistry. CRC Press, New York pp33-62.
   
• Carvan MJ, Gallagher E, Goksoyr A, Hahn M, Larsson DGJ and Wirgin I. Fish models in toxicology: a roundtable discussion. Zebrafish. 4, 9-20.
   
• Larsson J., Norrgren L. and Förlin L. 2005. (English revised version 2006). Hormones and Endocrine disrupting substances in the Environment.Chapter 6, p 84-103. (Invited review) In: Environment and Pharmaceuticals (ed. Wall T.). Apoteksbolaget, Stockholm. Available in English or Swedish from Apoteksbolaget AB, Sweden.
   
• Goksøyr A., Arukwe A., Larsson D.G.J., Cajaraville M.P., Hauser L., Nilsen B.M., Lowe D. and Matthiessen P. 2003. Molecular/cellular processes and the impact on reproduction. In: Effects of pollution on fish. Blackwell Science Ltd. pp 179-220. ISBN 0-632-06406-4.
   
• Larsson D.G.J. 2000. PhD-Thesis: Endocrine disruption in fish: sex ratios, secondary sex characters and estrogen-induced proteins. Göteborg University. ISBN 91-628-4104-1.
   

Original papers (refereed)

• Albertsson E, Larsson DGJ and Förlin L. Induction of hepatic carbonyl reductase/20β-hydroxysteroid dehydrogenase mRNA in rainbow trout downstream from sewage treatment works – possible roles of aryl hydrocarbon receptor agonists and oxidative stress. Aquatic Toxicology. In press.
   
• Friberg P.A., Larsson D.G.J., Billig H. 2009. Transcriptional effects of progesterone receptor antagonist in rat granulosa cells. Molecular and Cellular Endocrinology. In press.
   
• Nutu M, Weijdegård B, Thomas P, Thurin-Kjellberg A, Billig H and Larsson DGJ. 2009. Distribution and hormonal regulation of membrane progesterone receptors beta and gamma in ciliated epithelial cells of mouse and human fallopian tubes. Reproductive Biology and Endocrinology. In press.
   
• Kristiansson E, Asker N, Förlin L, Larsson DGJ. 2009. Characterization of the Zoarces viviparus liver transcriptome using massively parallel pyrosequencing. BMC Genomics. In press
   
• Gunnarsson L, Kristiansson E, Rutgersson C, Sturve J, Fick J, Förlin L, Larsson DGJ. 2009. Pharmaceutical industry effluent diluted 1:500 affects global gene expression, cytochrome P450 1A activity and plasma phosphate in fish. Environmental Toxicology and Chemistry. In press. doi: 10.1897/09-120.1
   
• Gunnarsson L, Adolfsson-Erici M, Björlenius B, Rutgersson C, Förlin L, Larsson DGJ. 2009. Comparison of six different sewage treatment processes—Reduction of estrogenic
  substances and effects on gene expression in exposed male fish. Science of the Total Environment. In press. doi:10.1016/j.scitotenv.2009.06.018
  
   
• Jerker Fick, Hanna Söderström, Richard H. Lindberg, Chau Phan, Mats Tysklind, and D. G. Joakim Larsson. 2009. Contamination of surface, ground, and drinking water from pharmaceutical production. Environmental Toxiclology and Chemistry. In press. DOI: 10.1897/09-073.1
   
• Larsson DGJ, Fick J 2009. Transparency throughout the production chain - a way to reduce pollution from the manufacturing of pharmaceuticals? Regulatory Toxicology and Pharmacology. In press. DOI: 10.1016/j.yrtph.2009.01.008.
   
• Carlsson, G., Örn, S., Larsson, D.G.J. 2009. Effluent from bulk drug production is toxic to aquatic vertebrates. In press. Environmental Toxicology and Chemistry.  
   
• Friberg P.A., Larsson D.G., Billig H., 2009. Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis. Biol Reprod. 80, 1160-1167.
   
• Gunnarsson L, Jauhiainen A, Kristiansson E, Nerman O, Larsson DGJ. 2008. Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environmental Science and Technology 42:5807-5813.
   
• D.G. J. Larsson, C. de Pedro, N. Paxeus. 2007. Effluent from drug manufactures contains extremely high levels of pharmaceuticals. Journal of Hazardous Materials. 148, 751-755.
   
• Brown JN, Paxeus N, Forlin L and Larsson DGJ. 2007. Variations in bioconcentration of human pharmaceuticals from sewage effluents into fish blood plasma. Environmental Toxicology and Pharmacology. 24, 267-274.
   
• Albertsson E., Kling P., Gunnarsson L., Larsson D.G.J. and Förlin L. 2007. Proteomic analyses indicate induction of hepatic carbonyl reductase/20β-hydroxysteroid dehydrogenase B in rainbow trout exposed to sewage effluent. Ecotoxicology and Environmental Safety. 68, 33-39.
   
• Gunnarsson L., Kristiansson E., Förlin L., Nerman O. and Larsson D.G.J. 2007. Sensitive and robust gene expression changes in fish exposed to estrogen: a microarray approach. BMC Genomics 8, 149.
   
• Friberg P.A., Larsson D.G.J., Rung E. and Billig H. 2007. Apoptotic effects of a progesterone receptor antagonist on rat granulosa cells are not mediated via reduced cholesterol synthesis and protein isoprenylation. Molecular Reproduction and Development. 74, 1317-1326.
   
• Nutu M., Weijdegård B., Thomas P., Bergh C., Thurin-Kjellberg A., Pang Y., Billig H. and Larsson D.G.J. 2007. Membrane progesterone receptor gamma: tissue distribution and expression in ciliated cells in the fallopian tube. Molecular Reproduction and Development. 74:843-850.
   
• Larsson D.G.J., Fredriksson S., Sandblom E., Paxeus N. and Axelsson M. 2006. Is heart rate in fish a sensitive indicator to evaluate acute effects of β-blockers in surface water? Environmental Toxicology and Pharmacology 22, 338-340.
   
• Samuelsson L., Förlin L., Karlsson G., Adolfsson-Erici M. and Larsson D.G.J. 2006. Using NMR metabolomics to identify responses of an environmental estrogen in blood plasma of fish. Aquatic Toxicology, 78, 341-349.
   
• Larsson D.G.J., Adolfsson-Erici M. and Thomas P. 2006. Characterization of putative ligands for a fish gonadal androgen receptor in pulp mill effluent. Environmental Toxicology and Chemistry 25, 269-27
   
• Markström E., Friberg P.A., Shao R., Larsson D.G.J., Nielsen E.C., Svensson P.-A., Carlsson B., Carlsson L.M.S and Billig H. 2005. Progesterone receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro. Biology of Reproduction. 72, 538-545.
   
• Larsson D.G.J., Sperry T. and Thomas P. 2002. Regulation of androgen receptors in Atlantic croaker brains by testosterone and estradiol. General and Comparative Endocrinology. 128, 224-230.
   
• Larsson D.G.J. and Förlin L. 2002. Male-biased sex ratios of fish embryos near a pulp mill: Temporary recovery after a short-term shutdown. Environmental Health Perspectives. 110, 739-742.
   
• Larsson D.G.J., Kinnberg K., Sturve J., Stephensen E., Skön M. and Förlin L. 2002. Studies of masculinization, detoxification and oxidative stress responses in guppies (Poecilia reticulata) exposed to effluent from a pulp mill. Ecotoxicology and Environmental Safety. 52, 13-20.
   
• Larsson D.G.J., Mayer I., Hyllner S.-J. and Förlin L. 2002. Seasonal variations of vitelline envelope proteins, vitellogenin and reproductive steroids in male and female eelpout (Zoarces viviparus). General and Comparative Endocrinology 125, 184-196.
   
• Larsson D.G.J., Hällman H. and Förlin L. 2000. More male fish embryos near a pulp mill. Environmental Toxicology and Chemistry 19 (12), 2911–2917.
   
• Livingstone D.R., Mitchelmore C.S., Peters L.D., O’Hara S.C.M., Shaw J., Chesman B., MacEvoy J., Ronisz D., Larsson D.G.J., and Förlin, L. 2000. Development of hepatic CYP1A and blood vitellogenin in eel (Anguilla anguilla) for use as biomarkers in the Thames estuary, UK. Marine Environmental Research, 50, 367-371.
   
• Larsson D.G.J., Adolfsson-Erici M., Parkkonen J., Pettersson, M., Berg H., Olsson P.-E. and Förlin L. 1999. Ethinyloestradiol - an undesired fish contraceptive? Aquatic Toxicology 45 (2-3), 91-97.
   
• Ronisz D., Larsson D.G.J. and Förlin, L. 1999. Seasonal variations in the activities of selected hepatic biotransformation and antioxidant enzymes in eelpout (Zoarces viviparus). Comparative Biochemistry and Physiology 124C, 271-279.
   
• Norrgren, L., Blom, A., Andersson, P.L., Börjesson, H., Larsson, D.G.J. and Olsson, P.-E. 1999. Effects of potential xenoestrogens (DEHP, nonylphenol and PCB) on sexual differentiation in juvenile Atlantic salmon (Salmo salar). Aquatic Ecosystem Health and Management 2, 311-317.
   
• Larsson D.G.J., Mylonas C.C., Zohar Y. and Crim L.W. 1997. Gonadotropin releasing hormone-analogue (GnRH-A) induces multiple ovulations of high quality eggs in a cold-water batch-spawning teleost, the yellowtail flounder (Pleuronectes ferrugineus). Canadian Journal of Fisheries an Aquatic Sciences 54 (9), 1957-196.
   
• Hyllner S.J., Fernandez-Palacios Barber H., Larsson D.G.J. and Haux C. 1995. Amino acid composition and endocrine control of vitelline envelope proteins in European sea bass (Dicentrarchus labrax) and gilthead sea bream (Sparus aurata). Molecular Reproduction and Development 41, 339-347.
   
• Larsson D.G.J., Hyllner S.J. and Haux C. 1994. Induction of vitelline envelope proteins by estradiol-17 in ten teleost species. General and Comparative Endocrinology 96, 445-450.